Two mouse models of Alzheimer's disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein.

Two mouse models of Alzheimer's disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein.

Oligomers formed from monomers of the amyloid β-protein (Aβ) are thought to be central to the pathogenesis of Alzheimer's disease (AD). Unsurprisingly for a complex disease, current mouse models of AD fail to fully mimic the clinical disease in humans. Moreover, results obtained in a given mous...

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Bibliographic Details
Main Authors: Silvia A Purro, Michael Farmer, Elizabeth Noble, Claire J Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X Thomas, Mark Farrow, Andrew J Nicoll, Dominic Walsh, John Collinge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0294465

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https://doi.org/10.1371/journal.pone.0294465

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