Designed α-sheet peptides disrupt uropathogenic E. coli biofilms rendering bacteria susceptible to antibiotics and immune cells

Abstract Uropathogenic Escherichia coli account for the largest proportion of nosocomial infections in the United States. Nosocomial infections are a major source of increased costs and treatment complications. Many infections are biofilm associated, rendering antibiotic treatments ineffective or ca...

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Bibliographic Details
Main Authors: Alissa Bleem, Tatum Prosswimmer, Ruying Chen, Thomas F. Hady, Jinzheng Li, James D. Bryers, Valerie Daggett
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-36343-6