Efferocytosis drives myeloid NLRP3 dependent inflammasome signaling secretion of IL-1β to promote tumor growth

Efferocytosis drives myeloid NLRP3 dependent inflammasome signaling secretion of IL-1β to promote tumor growth

Caspase-1 signaling in myeloid suppressor cells can promote T-cell independent cancer progression, but the regulation of inflammasome signaling within the highly heterogeneous myeloid population in the tumor milieu remains elusive. To resolve this complexity, single cell transcriptomic profile of He...

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Bibliographic Details
Main Authors: Cara Lang, Sohini Roy, Yu Wang, Diana Graves, Yaomin Xu, C. Henrique Serezani, Michael Korrer, Young J. Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
inflammasome
efferocytosis
NLRP3
IL-1β
immunotherapy
tumor associated macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.993771/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.993771/full

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