JAFFAL: detecting fusion genes with long-read transcriptome sequencing

JAFFAL: detecting fusion genes with long-read transcriptome sequencing

Abstract In cancer, fusions are important diagnostic markers and targets for therapy. Long-read transcriptome sequencing allows the discovery of fusions with their full-length isoform structure. However, due to higher sequencing error rates, fusion finding algorithms designed for short reads do not...

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Bibliographic Details
Main Authors: Nadia M. Davidson, Ying Chen, Teresa Sadras, Georgina L. Ryland, Piers Blombery, Paul G. Ekert, Jonathan Göke, Alicia Oshlack
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Genome Biology
Subjects:
Fusions
Translocations
RNA sequencing
Long reads
Nanopore
PacBio
Online Access:https://doi.org/10.1186/s13059-021-02588-5

Internet

https://doi.org/10.1186/s13059-021-02588-5

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