Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin

Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin

Despite extensive treatment, glioblastoma inevitably recurs, leading to an overall survival of around 16 months. Understanding why and how tumours resist to radio/chemotherapies is crucial to overcome this unmet oncological challenge. Primary and acquired resistance to Temozolomide (TMZ), the standa...

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Bibliographic Details
Main Authors: Saidu Sani, Nikita Pallaoro, Mélissa Messe, Chloé Bernhard, Nelly Etienne-Selloum, Horst Kessler, Luciana Marinelli, Natacha Entz-Werle, Sophie Foppolo, Sophie Martin, Damien Reita, Monique Dontenwill
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
glioblastoma
temozolomide resistance
integrins
p53 reactivation
Online Access:https://www.mdpi.com/2072-6694/14/2/369

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https://www.mdpi.com/2072-6694/14/2/369

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