The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas

Testicular germ cell tumors (GCTs) are stratified into seminomas and nonseminomas. Seminomas share many histological and molecular features with primordial germ cells, whereas the nonseminoma stem cell population—embryonal carcinoma (EC)—is pluripotent and thus able to differentiate into cells of al...

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Bibliographic Details
Main Authors: Margaretha A. Skowron, Teresa K. Becker, Lukas Kurz, Sina Jostes, Felix Bremmer, Florian Fronhoffs, Kai Funke, Gamal A. Wakileh, Melanie R. Müller, Aaron Burmeister, Thomas Lenz, Anja Stefanski, Kai Stühler, Patrick Petzsch, Karl Köhrer, Peter Altevogt, Peter Albers, Glen Kristiansen, Hubert Schorle, Daniel Nettersheim
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Molecular Oncology
Subjects:
CD24
differentiation
embryonal carcinoma
epigenetics
germ cell tumors
microenvironment
Online Access:https://doi.org/10.1002/1878-0261.13066

Internet

https://doi.org/10.1002/1878-0261.13066

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