Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers

Target Antigen Attributes and Their Contributions to Clinically Approved Antibody-Drug Conjugates (ADCs) in Haematopoietic and Solid Cancers

Antibody drug conjugates (ADCs) are powerful anti-cancer therapies comprising an antibody joined to a cytotoxic payload through a chemical linker. ADCs exploit the specificity of antibodies for their target antigens, combined with the potency of cytotoxic drugs, to selectively kill target antigen-ex...

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Bibliographic Details
Main Authors: Benjamina Esapa, Jiexuan Jiang, Anthony Cheung, Alicia Chenoweth, David E. Thurston, Sophia N. Karagiannis
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cancers
Subjects:
monoclonal antibodies
mAb
antibody-drug conjugates (ADCs)
Fab regions
antigen
target
Online Access:https://www.mdpi.com/2072-6694/15/6/1845

Internet

https://www.mdpi.com/2072-6694/15/6/1845

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