Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics

Multiparameter Optimization of Trypanocidal Cruzain Inhibitors With In Vivo Activity and Favorable Pharmacokinetics

Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of the parasite’s life cycle, including nutrition acquisition, differentiation, evasion of the host immune system, and invasion of host cells. Thus, inhibition of this validated target may lead to the development...

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গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Ivani Pauli, Celso de O. Rezende Jr., Brian W. Slafer, Marco A. Dessoy, Mariana L. de Souza, Leonardo L. G. Ferreira, Abraham L. M. Adjanohun, Rafaela S. Ferreira, Luma G. Magalhães, Renata Krogh, Simone Michelan-Duarte, Ricardo Vaz Del Pintor, Fernando B. R. da Silva, Fabio C. Cruz, Luiz C. Dias, Adriano D. Andricopulo
বিন্যাস: প্রবন্ধ
ভাষা:English
প্রকাশিত: Frontiers Media S.A. 2022-01-01
মালা:Frontiers in Pharmacology
বিষয়গুলি:
chagas disease
cruzain
medicinal chemistry
drug design
multiparameter optimization
pharmacokinetics
অনলাইন ব্যবহার করুন:https://www.frontiersin.org/articles/10.3389/fphar.2021.774069/full

আন্তর্জাল

https://www.frontiersin.org/articles/10.3389/fphar.2021.774069/full

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