Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis

Active Tumor-Targeting Nano-formulations Containing Simvastatin and Doxorubicin Inhibit Melanoma Growth and Angiogenesis

Primary melanoma aggressiveness is determined by rapid selection and growth of cellular clones resistant to conventional treatments, resulting in metastasis and recurrence. In addition, a reprogrammed tumor-immune microenvironment supports melanoma progression and response to therapy. There is an ur...

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Bibliographic Details
Main Authors: Giorgiana Negrea, Valentin-Florian Rauca, Marta Szilvia Meszaros, Laura Patras, Lavinia Luput, Emilia Licarete, Vlad-Alexandru Toma, Alina Porfire, Dana Muntean, Alina Sesarman, Manuela Banciu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
melanoma
drug delivery systems
liposomes
extracellular vesicles
simvastatin
doxorubicin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.870347/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.870347/full

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