Concurrent predictors of an immune responsive tumor microenvironment within tumor mutational burden-high breast cancer

Concurrent predictors of an immune responsive tumor microenvironment within tumor mutational burden-high breast cancer

BackgroundData supporting high tumor mutational burden (TMB-H) as a lone biomarker for an immune-responsive tumor microenvironment (TME) in metastatic breast cancer (MBC) are weak, yet tumor agnostic approval in TMB-H advanced tumors provides immune checkpoint inhibition (ICI) as a clinical option....

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Bibliographic Details
Main Authors: Sarah Sammons, Andrew Elliott, Romualdo Barroso-Sousa, Saranya Chumsri, Antoinette R. Tan, George W. Sledge, Sara M. Tolaney, Evanthia T. Roussos Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
breast cancer
tumor mutational burden
genetic profiling
microenvironment
immune checkpoint inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1235902/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1235902/full

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