Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells

Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in human lung epithelial cells. In the present stu...

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Bibliographic Details
Main Authors: Mengyao Li, Mohammad A. K. Azad, Maizbha U. Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, Hak-Kim Chan, Tony Velkov, Qi Tony Zhou, Jian Li
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antibiotics
Subjects:
polymyxin
pulmonary toxicity
transcriptomics
lung epithelial cells
Online Access:https://www.mdpi.com/2079-6382/11/3/307

Internet

https://www.mdpi.com/2079-6382/11/3/307

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