Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA.

In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed. Slowing of replication allows for tolerance of DNA damage and suppresses genomic instability....

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Bibliografske podrobnosti
Main Authors: Divya Ramalingam Iyer, Nicholas Rhind
Format: Article
Jezik:English
Izdano: Public Library of Science (PLoS) 2017-08-01
Serija:PLoS Genetics
Online dostop:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1006958&type=printable