Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production

Rewiring Saccharomyces cerevisiae metabolism for optimised Taxol® precursors production

Saccharomyces cerevisiae has been conveniently used to produce Taxol® anticancer drug early precursors. However, the harmful impact of oxidative stress by the first cytochrome P450-reductase enzymes (CYP725A4-POR) of Taxol® pathway has hampered sufficient progress in yeast. Here, we evolved an oxida...

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Bibliographic Details
Main Authors: Behnaz Nowrouzi, Pablo Torres-Montero, Eduard J. Kerkhoven, José L. Martínez, Leonardo Rios-Solis
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Metabolic Engineering Communications
Subjects:
Saccharomyces cerevisiae
Taxol®
Taxadiene
Oxidative stress
Adaptive laboratory evolution
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030123000123

Internet

http://www.sciencedirect.com/science/article/pii/S2214030123000123

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