Comparative Proteomics of Extended-Spectrum Cephalosporin-Resistant Neisseria gonorrhoeae Isolates Demonstrates Altered Protein Synthesis, Metabolism, Substance Transport, and Membrane Permeability

Comparative Proteomics of Extended-Spectrum Cephalosporin-Resistant Neisseria gonorrhoeae Isolates Demonstrates Altered Protein Synthesis, Metabolism, Substance Transport, and Membrane Permeability

Neisseria gonorrhoeae isolates exhibit resistance to extended-spectrum cephalosporins (ESCs), the last remaining option for first-line empirical monotherapy. Here, we investigated the proteomic profiles of N. gonorrhoeae clinical isolates with ESC-resistance to support exploration of the antimicrobi...

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Bibliographic Details
Main Authors: Nannan Diao, Guoquan Yan, Yang Yang, Yuan Dong, Ying Wang, Weiming Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Microbiology
Subjects:
Neisseria gonorrhoeae
extended-spectrum cephalosporin resistance
comparative proteomics
iTRAQ
metabolism
membrane permeability
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00169/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00169/full

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