R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.

R-loops and regulatory changes in chronologically ageing fission yeast cells drive non-random patterns of genome rearrangements.

Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing. Rearrangements are challenging to detect in non-dividing cell populations, because they reflect individually rare, heterogene...

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Bibliographic Details
Main Authors: David A Ellis, Félix Reyes-Martín, María Rodríguez-López, Cristina Cotobal, Xi-Ming Sun, Quentin Saintain, Daniel C Jeffares, Samuel Marguerat, Víctor A Tallada, Jürg Bähler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009784

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https://doi.org/10.1371/journal.pgen.1009784

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