Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway

Placental Mesenchymal Stem Cells Alleviate Podocyte Injury in Diabetic Kidney Disease by Modulating Mitophagy via the SIRT1-PGC-1alpha-TFAM Pathway

The use of mesenchymal stem cells (MSCs) has become a new strategy for treating diabetic kidney disease (DKD). However, the role of placenta derived mesenchymal stem cells (P-MSCs) in DKD remains unclear. This study aims to investigate the therapeutic application and molecular mechanism of P-MSCs on...

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Bibliographic Details
Main Authors: Xiudan Han, Jiao Wang, Ruilin Li, Meiling Huang, Guanru Yue, Lulu Guan, Yuanyuan Deng, Wei Cai, Jixiong Xu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic kidney disease
placenta derived mesenchymal stem cells
podocyte injury
mitophagy
SIRT1-PGC-1α-TFAM pathway
Online Access:https://www.mdpi.com/1422-0067/24/5/4696

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https://www.mdpi.com/1422-0067/24/5/4696

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