α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting

Despite the development of metabolism-based therapy for a variety of malignancies, resistance to single-agent treatment is common due to the metabolic plasticity of cancer cells. Improved understanding of how malignant cells rewire metabolic pathways can guide the rational selection of combination t...

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Bibliographic Details
Main Authors: Yanwu Wang, Ning Shen, Gervase Spurlin, Sovannarith Korm, Sarah Huang, Nicole M. Anderson, Leah N. Huiting, Hudan Liu, Hui Feng
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
TCA cycle
T-cell acute lymphoblastic leukemia
α-ketoglutarate
DNA demethylation
oxidative phosphorylation
reductive carboxylation
Online Access:https://www.mdpi.com/2072-6694/14/12/2983

Internet

https://www.mdpi.com/2072-6694/14/12/2983

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