Heparinized chitosan stabilizes the bioactivity of BMP-2 and potentiates the osteogenic efficacy of demineralized bone matrix

Heparinized chitosan stabilizes the bioactivity of BMP-2 and potentiates the osteogenic efficacy of demineralized bone matrix

Abstract Background Demineralized bone matrix (DBM), an allograft bone processed to better expose osteoinductive factors such as bone morphogenetic proteins (BMPs), is increasingly used for clinical bone repair. However, more extensive use of DBM is limited by its unpredictable osteoinductivity and...

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Bibliographic Details
Main Authors: Soyon Kim, Jiabing Fan, Chung-Sung Lee, Chen Chen, Ksenia Bubukina, Min Lee
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Biological Engineering
Subjects:
Heparin
Hydrogel
Bone morphogenetic protein
Demineralized bone matrix
Osteogenesis
Online Access:http://link.springer.com/article/10.1186/s13036-020-0231-y

Internet

http://link.springer.com/article/10.1186/s13036-020-0231-y

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