Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive “superbug”, and no promising NDM-1 inhibitors were used in clinical practice...

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Bibliographic Details
Main Authors: Bing Zhao, Xinhui Zhang, Tingting Yu, Ying Liu, Xiaoling Zhang, Yongfang Yao, Xuejian Feng, Hongmin Liu, Dequan Yu, Liying Ma, Shangshang Qin
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Thiosemicarbazone derivatives
New Delhi metallo-β-lactamase-1
Inhibitor
Antibiotic resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520306316

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http://www.sciencedirect.com/science/article/pii/S2211383520306316

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