Pro-Oxidant Activity of Amine-Pyridine-Based Iron Complexes Efficiently Kills Cancer and Cancer Stem-Like Cells.

Pro-Oxidant Activity of Amine-Pyridine-Based Iron Complexes Efficiently Kills Cancer and Cancer Stem-Like Cells.

Differential redox homeostasis in normal and malignant cells suggests that pro-oxidant-induced upregulation of cellular reactive oxygen species (ROS) should selectively target cancer cells without compromising the viability of untransformed cells. Consequently, a pro-oxidant deviation well-tolerated...

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Bibliographic Details
Main Authors: Marta González-Bártulos, Clara Aceves-Luquero, Jamal Qualai, Olaf Cussó, M Angeles Martínez, Silvia Fernández de Mattos, Javier A Menéndez, Priam Villalonga, Miquel Costas, Xavi Ribas, Anna Massaguer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4569415?pdf=render

Internet

http://europepmc.org/articles/PMC4569415?pdf=render

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