Evaluation of Hydroxyl Radical Reactivity by Thioether Group Proximity in Model Peptide Backbone: Methionine versus S-Methyl-Cysteine

Evaluation of Hydroxyl Radical Reactivity by Thioether Group Proximity in Model Peptide Backbone: Methionine versus S-Methyl-Cysteine

Hydroxyl radicals (HO<sup>•</sup>) have long been regarded as a major source of cellular damage. The reaction of HO<sup>•</sup> with methionine residues (Met) in peptides and proteins is a complex multistep process. Although the reaction mechanism has been intensively studied...

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Bibliographic Details
Main Authors: Chryssostomos Chatgilialoglu, Magdalena Grzelak, Konrad Skotnicki, Piotr Filipiak, Franciszek Kazmierczak, Gordon L. Hug, Krzysztof Bobrowski, Bronislaw Marciniak
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
methionine
S-methyl-cysteine
pulse and γ-radiolysis
oxidation
free radicals
high-resolution MS/MS
Online Access:https://www.mdpi.com/1422-0067/23/12/6550

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https://www.mdpi.com/1422-0067/23/12/6550

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