Pareto task inference analysis reveals cellular trade-offs in diffuse large B-Cell lymphoma transcriptomic data

One of the main challenges in cancer treatment is the selection of treatment resistant clones which leads to the emergence of resistance to previously efficacious therapies. Identifying vulnerabilities in the form of cellular trade-offs constraining the phenotypic possibility space could allow to av...

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Bibliographic Details
Main Authors: Jonatan Blais, Julie Jeukens
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Systems Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fsysb.2024.1346076/full