Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation

Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation

Abstract Background Astrocytes respond to injury and disease through a process known as reactive astrogliosis, of which inflammatory signaling is one subset. This inflammatory response is heterogeneous with respect to the inductive stimuli and the afflicted central nervous system region. This is of...

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Bibliographic Details
Main Authors: Caroline Lindblad, Susanne Neumann, Sólrún Kolbeinsdóttir, Vasilios Zachariadis, Eric P. Thelin, Martin Enge, Sebastian Thams, Lou Brundin, Mikael Svensson
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Inflammation
Subjects:
Embryonic stem cells
Disease modelling
Traumatic axonal injury
Ventral brainstem- or rostroventral spinal astrocytes
Astrocytes
Neuroinflammation
Online Access:https://doi.org/10.1186/s12950-023-00349-8

Internet

https://doi.org/10.1186/s12950-023-00349-8

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