Periosteum-inspired in situ CaP generated nanocomposite hydrogels with strong bone adhesion and superior stretchability for accelerated distraction osteogenesis

Periosteum-inspired in situ CaP generated nanocomposite hydrogels with strong bone adhesion and superior stretchability for accelerated distraction osteogenesis

Abstract Background Distraction osteogenesis (DO) is an efficacious but lengthy procedure to reconstruct segmental bone defects under the principle of tension-stress, during which the periosteum-mediated mechanical stimulation plays a pivotal role. Inspired by the dynamic process of DO and the mecha...

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Bibliographic Details
Main Authors: Tengfei Lou, Kai Chen, Qiyu Luo, Changsheng Liu, Yuan Yuan, Cunyi Fan
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2022-12-01
Series:Biomaterials Research
Subjects:
In situ precipitated CaP nanoparticles
Nanocomposite hydrogels
Bone adhesion
Stretchability
Dynamic distraction osteogenesis
Mechanical stimulation
Online Access:https://doi.org/10.1186/s40824-022-00330-1

Internet

https://doi.org/10.1186/s40824-022-00330-1

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