Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

<p>Abstract</p> <p>Background</p> <p>Notch1 is a potent regulator known to play an oncogenic role in many malignancies including T-cell acute lymphoblastic leukemia (T-ALL). Tumor hypoxia and increased hypoxia-inducible factor-1α (HIF-1α) activity can act as major stimu...

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Bibliographic Details
Main Authors: Zou Jie, Li Peng, Lu Fei, Liu Na, Dai Jianjian, Ye Jingjing, Qu Xun, Sun Xiulian, Ma Daoxin, Park Jino, Ji Chunyan
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Journal of Hematology & Oncology
Subjects:
T-cell acute lymphoblastic leukemia
Hypoxia
HIF-1α
Notch1
Proliferation
Invasion
Chemoresistance
Online Access:http://www.jhoonline.org/content/6/1/3

Internet

http://www.jhoonline.org/content/6/1/3

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