GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.

GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice.

Peroxisome proliferator-activated receptors (PPARs) are a nuclear receptor family of ligand-inducible transcription factors, which have three different isoforms: PPARα, δ and γ. It has been demonstrated that PPARα and γ agonists have renoprotective effects in proteinuric kidney diseases; however, th...

Full description

Bibliographic Details
Main Authors: Xu Yang, Shinji Kume, Yuki Tanaka, Keiji Isshiki, Shin-ichi Araki, Masami Chin-Kanasaki, Toshiro Sugimoto, Daisuke Koya, Masakazu Haneda, Takeshi Sugaya, Detian Li, Ping Han, Yoshihiko Nishio, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uzu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3178624?pdf=render

Internet

http://europepmc.org/articles/PMC3178624?pdf=render

Similar Items