P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

P1′ Residue-Oriented Virtual Screening for Potent and Selective Phosphinic (Dehydro) Dipeptide Inhibitors of Metallo-Aminopeptidases

Designing side chain substituents complementary to enzyme binding pockets is of great importance in the construction of potent and selective phosphinic dipeptide inhibitors of metallo-aminopeptidases. Proper structure selection makes inhibitor construction more economic, as the development process t...

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Bibliographic Details
Main Authors: Michał Talma, Artur Mucha
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
organophosphorus compounds
peptide analogs
enzyme inhibitors
ligand–enzyme interactions
molecular modeling and docking
Online Access:https://www.mdpi.com/2218-273X/10/4/659

Internet

https://www.mdpi.com/2218-273X/10/4/659

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