<em>GPX3</em> rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy

<em>GPX3</em> rs8177412 Polymorphism Modifies Risk of Upper Urothelial Tumors in Patients with Balkan Endemic Nephropathy

Current data suggest that aristolochic acid (AA) exposure is a putative cause of Balkan endemic nephropathy (BEN), a chronic kidney disease strongly associated with upper tract urothelial carcinoma. The cellular metabolism of AA is associated with the production of reactive oxygen species, resulting...

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Bibliographic Details
Main Authors: Zana Radic Savic, Vesna Coric, Stojko Vidovic, Vanja Vidovic, Jelena Becarevic, Irina Milovac, Zorica Reljic, Bosa Mirjanic-Azaric, Ranko Skrbic, Radoslav Gajanin, Marija Matic, Tatjana Simic
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Medicina
Subjects:
Balkan endemic nephropathy
upper tract urothelial cell carcinoma
aristolochic acid
<i>GPX3</i> polymorphism
Online Access:https://www.mdpi.com/1648-9144/59/8/1421

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https://www.mdpi.com/1648-9144/59/8/1421

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