Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice

Adenosine A2A Receptor Deletion Blocks the Beneficial Effects of Lactobacillus reuteri in Regulatory T-Deficient Scurfy Mice

The lack of a functional Foxp3 transcription factor and regulatory T (Treg) cells causes lethal, CD4+ T cell-driven autoimmune diseases in scurfy (SF) mice and humans. Recent studies have shown that adenosine A2A receptor activation limits inflammation and tissue damage, thereby playing an anti-infl...

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Bibliographic Details
Main Authors: Baokun He, Thomas K. Hoang, Dat Q. Tran, Jon Marc Rhoads, Yuying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
regulatory T deficiency
autoimmunity
adenosine A2A receptor
Lactobacillus reuteri
cytokines
IPEX
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01680/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01680/full

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