Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain

Abstract Background Although a large amount of evidence has revealed that amyloid β (Aβ), especially Aβ oligomers, protofibrils, and pyroglutamated Aβs, participate primarily in the pathophysiological processes of Alzheimer’s disease, most clinical trials of anti-Aβ antibody therapy have never acqui...

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Bibliographic Details
Main Authors: Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, Takanori Yokota
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Nanobiotechnology
Subjects:
Alzheimer’s disease
Polymeric nanomicelle
Amyloid β oligomer
Pyroglutamated amyloid β
Online Access:https://doi.org/10.1186/s12951-023-01772-y

Internet

https://doi.org/10.1186/s12951-023-01772-y

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