11p15 Epimutations in Pediatric Embryonic Tumors: Insights from a Methylome Analysis

11p15 Epimutations in Pediatric Embryonic Tumors: Insights from a Methylome Analysis

Embryonic tumors share few recurrent mutations, suggesting that other mechanisms, such as aberrant DNA methylation, play a prominent role in their development. The loss of imprinting (LOI) at the chromosome region 11p15 is the germline alteration behind Beckwith–Wiedemann syndrome that results in an...

Full description

Bibliographic Details
Main Authors: Felipe Luz Torres Silva, Juliana Silveira Ruas, Mayara Ferreira Euzébio, Iva Loureiro Hoffmann, Thais Junqueira, Helder Tedeschi, Luiz Henrique Pereira, Alejandro Enzo Cassone, Izilda Aparecida Cardinalli, Ana Luiza Seidinger, Patricia Yoshioka Jotta, Mariana Maschietto
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
11p15
ICR1
ICR2
DNA methylation
embryonic tumors
medulloblastoma
Online Access:https://www.mdpi.com/2072-6694/15/17/4256

Internet

https://www.mdpi.com/2072-6694/15/17/4256

Similar Items