Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A<sub>2B</sub> Adenosine Receptor

Intraglomerular Monocyte/Macrophage Infiltration and Macrophage–Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A<sub>2B</sub> Adenosine Receptor

Diabetic nephropathy (DN) is considered the main cause of kidney disease in which myofibroblasts lead to renal fibrosis. Macrophages were recently identified as the major source of myofibroblasts in a process known as macrophage–myofibroblast transition (MMT). Adenosine levels increase during DN and...

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Bibliographic Details
Main Authors: Ángelo Torres, Katherin Muñoz, Yessica Nahuelpán, Angelo-Paolo R. Saez, Pablo Mendoza, Claudia Jara, Claudio Cappelli, Raibel Suarez, Carlos Oyarzún, Claudia Quezada, Rody San Martín
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
adenosine
A<sub>2B</sub> adenosine receptor
diabetic kidney disease
glomerulosclerosis
macrophage–myofibroblast transition
Online Access:https://www.mdpi.com/2073-4409/9/4/1051

Internet

https://www.mdpi.com/2073-4409/9/4/1051

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