WQ-3810, a fluoroquinolone with difluoropyridine derivative as the R1 group exerts high potency against quinolone-resistant Campylobacter jejuni

WQ-3810, a fluoroquinolone with difluoropyridine derivative as the R1 group exerts high potency against quinolone-resistant Campylobacter jejuni

ABSTRACT Quinolone-resistant Campylobacter jejuni have been increasing worldwide. Quinolones exert their antibacterial activity by inhibiting DNA gyrase, but most of the isolates acquire quinolone resistance via an amino acid substitution in the A subunit of DNA gyrase. WQ-3810 is a quinolone antibi...

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Bibliographic Details
Main Authors: Kentaro Koide, Hyun Kim, Matthew V. X. Whelan, Lawrence P. Belotindos, Wimonrat Tanomsridachchai, Ruchirada Changkwanyeun, Masaru Usui, Tadhg Ó Cróinín, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:Microbiology Spectrum
Subjects:
antimicrobial resistance
quinolone
Campylobacter jejuni
DNA gyrase
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04322-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.04322-23

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