A Splice Variant in <i>SLC16A8</i> Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells

A Splice Variant in <i>SLC16A8</i> Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells

Age-related macular degeneration (AMD) is a blinding disease for which most of the patients remain untreatable. Since the disease affects the macula at the center of the retina, a structure specific to the primate lineage, rodent models to study the pathophysiology of AMD and to develop therapies ar...

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Bibliographic Details
Main Authors: Laurence Klipfel, Marie Cordonnier, Léa Thiébault, Emmanuelle Clérin, Frédéric Blond, Géraldine Millet-Puel, Saddek Mohand-Saïd, Olivier Goureau, José-Alain Sahel, Emeline F. Nandrot, Thierry Léveillard
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
retinal pigment epithelium
lactate transport
induced pluripotent stem cells
splicing
MCT3
age-related macular degeneration
Online Access:https://www.mdpi.com/2073-4409/10/1/179

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https://www.mdpi.com/2073-4409/10/1/179

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