Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents

Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents

The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf. Iron is required for multiple cellular processes...

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Bibliographic Details
Main Authors: Pierre V. Candelaria, Lai Sum Leoh, Manuel L. Penichet, Tracy R. Daniels-Wells
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
cancer
transferrin receptor
iron deprivation
CD71
antibody-mediated effector functions
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.607692/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.607692/full

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