Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in <i>Enterococcus faecalis</i>

Unveiling the Relationship between Ceftobiprole and High-Molecular-Mass (HMM) Penicillin-Binding Proteins (PBPs) in <i>Enterococcus faecalis</i>

Low-affinity PBP4, historically linked to penicillin resistance in <i>Enterococcus faecalis</i>, may still have affinity for novel cephalosporins. Ceftobiprole (BPR) is a common therapeutic choice, even with PBP4-related overexpression and amino acid substitution due to mutations. Our st...

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Bibliographic Details
Main Authors: Paola Conti, Lorenzo Mattia Lazzaro, Fabio Longo, Federica Lenzo, Alessandra Giardina, Sebastiano Alberto Fortuna, Stefania Stefani, Floriana Campanile
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antibiotics
Subjects:
<i>Enterococcus faecalis</i>
ceftobiprole
PBPs
competition assays
Bocillin
Online Access:https://www.mdpi.com/2079-6382/13/1/65

Internet

https://www.mdpi.com/2079-6382/13/1/65

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