Integrative Organelle-Based Functional Proteomics: In Silico Prediction of Impaired Functional Annotations in <i>SACS</i> KO Cell Model

Integrative Organelle-Based Functional Proteomics: In Silico Prediction of Impaired Functional Annotations in <i>SACS</i> KO Cell Model

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is an inherited neurodegenerative disease characterized by early-onset spasticity in the lower limbs, axonal-demyelinating sensorimotor peripheral neuropathy, and cerebellar ataxia. Our understanding of ARSACS (genetic basis, protein...

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Bibliographic Details
Main Authors: Federica Morani, Stefano Doccini, Daniele Galatolo, Francesco Pezzini, Rabah Soliymani, Alessandro Simonati, Maciej M. Lalowski, Federica Gemignani, Filippo M. Santorelli
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Biomolecules
Subjects:
ARSACS
<i>SACS</i>
KO models
omics
biomarkers
mitochondria
Online Access:https://www.mdpi.com/2218-273X/12/8/1024

Internet

https://www.mdpi.com/2218-273X/12/8/1024

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