Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors

Neuroplastin exerts antiepileptic effects through binding to the α1 subunit of GABA type A receptors to inhibit the internalization of the receptors

Abstract Background Seizures are associated with a decrease in γ-aminobutyric type A acid receptors (GABAaRs) on the neuronal surface, which may be regulated by enhanced internalization of GABAaRs. When interactions between GABAaR subunit α-1 (GABRA1) and postsynaptic scaffold proteins are weakened,...

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Bibliographic Details
Main Authors: Sijun Li, Xing Wei, Hongmi Huang, Lin Ye, Meigang Ma, Lanfeng Sun, Yuling Lu, Yuan Wu
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
Seizures
γ-aminobutyric type A acid receptors
Neuroplastin
Internalization
Online Access:https://doi.org/10.1186/s12967-023-04596-4

Internet

https://doi.org/10.1186/s12967-023-04596-4

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