Irreversible methadone-induced GSTP1 downregulation in SH-SY5Y cells

Irreversible methadone-induced GSTP1 downregulation in SH-SY5Y cells

Abstract Background Methadone has been reported to downregulate the expression of glutathione S-transferase P1 (GSTP1) among nine antioxidant genes in SH-SY5Y cells after both short- and long-term treatment. GSTP1 plays a key role in the detoxification of many xenobiotics and is frequently associate...

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Bibliographic Details
Main Authors: Khyber Saify, Mostafa Saadat
Format: Article
Language:English
Published: SpringerOpen 2024-03-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
GSTP1
Methylation
Methadone
SH-SY5Y
Online Access:https://doi.org/10.1186/s43042-024-00504-7

Internet

https://doi.org/10.1186/s43042-024-00504-7

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