Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.

Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.

Malaria vaccine candidate Apical Membrane Antigen-1 (AMA1) induces protection, but only against parasite strains that are closely related to the vaccine. Overcoming the AMA1 diversity problem will require an understanding of the structural basis of cross-strain invasion inhibition. A vaccine contain...

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Bibliographic Details
Main Authors: Sheetij Dutta, Lisa S Dlugosz, Damien R Drew, Xiaopeng Ge, Diouf Ababacar, Yazmin I Rovira, J Kathleen Moch, Meng Shi, Carole A Long, Michael Foley, James G Beeson, Robin F Anders, Kazutoyo Miura, J David Haynes, Adrian H Batchelor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3873463?pdf=render

Internet

http://europepmc.org/articles/PMC3873463?pdf=render

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