Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

De novo mutations in voltage- and ligand-gated channels have been associated with an increasing number of cases of developmental and epileptic encephalopathies, which often fail to respond to classic antiseizure medications. Here, we examine two knock-in mouse models replicating de novo sequence var...

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Bibliographic Details
Main Authors: Andrea Merseburg, Jacquelin Kasemir, Eric W Buss, Felix Leroy, Tobias Bock, Alessandro Porro, Anastasia Barnett, Simon E Tröder, Birgit Engeland, Malte Stockebrand, Anna Moroni, Steven A Siegelbaum, Dirk Isbrandt, Bina Santoro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
HCN1
ion channels
epileptic encephalopathy
lamotrigine
phenytoin
Dravet syndrome
Online Access:https://elifesciences.org/articles/70826

Internet

https://elifesciences.org/articles/70826

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