A Class I Histone Deacetylase Inhibitor Attenuates Insulin Resistance and Inflammation in Palmitate-Treated C2C12 Myotubes and Muscle of HF/HFr Diet Mice

A Class I Histone Deacetylase Inhibitor Attenuates Insulin Resistance and Inflammation in Palmitate-Treated C2C12 Myotubes and Muscle of HF/HFr Diet Mice

Histone deacetylase (HDAC) inhibitors, which regulate gene expression by inhibiting the deacetylation of histones and nonhistone proteins, have been shown to exert a wide array of biological effects; these include anti-cancer, anti-obesity, and anti-diabetes effects, as well as cardiovascular-protec...

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Bibliographic Details
Main Authors: Soo Jin Lee, Sung-E Choi, Han Byeol Lee, Min-Woo Song, Young Ha Kim, Jae Yeop Jeong, Yup Kang, Hae Jin Kim, Tae Ho Kim, Ja Young Jeon, Kwan Woo Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
Histone deacetylase inhibitor
MS-275
Insulin resistance
Inflammation
C2C12
Lipotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.601448/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.601448/full

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