Trametinib Induces the Stabilization of a Dual <i>GNAQ</i> p.Gly48Leu- and <i>FGFR4</i> p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

Trametinib Induces the Stabilization of a Dual <i>GNAQ</i> p.Gly48Leu- and <i>FGFR4</i> p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

We report a case of an uveal melanoma patient with <i>GNAQ</i> p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that Gα<sub>q</sub> can adopt active an...

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Bibliographic Details
Main Authors: Fanny S. Krebs, Camille Gérard, Alexandre Wicky, Veronica Aedo-Lopez, Edoardo Missiaglia, Bettina Bisig, Mounir Trimech, Olivier Michielin, Krisztian Homicsko, Vincent Zoete
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
precision oncology
molecular modelling
mutation
GNAQ
FGFR4
Online Access:https://www.mdpi.com/1422-0067/21/21/8021

Internet

https://www.mdpi.com/1422-0067/21/21/8021

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