Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells
The actin-remodelling protein L-plastin promotes tumour migration and invasion. Here, the authors show that L-plastin is regulated spatially by ROS-induced thiol oxidation which inhibits its actin-bundling function and cell spreading and filopodial extension formation in tumor cells.
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-09-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11909-z |