Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stages of the pathology. Hypothesis: We hypo...

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Bibliographic Details
Main Authors: Benjamin B. Tournier, Kelly Ceyzériat, Aurélien M. Badina, Yesica Gloria, Aïda B. Fall, Quentin Amossé, Stergios Tsartsalis, Philippe Millet
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:NeuroImage
Subjects:
Alzheimer's disease
TgF344-AD
Astrocytes
Dopamine
Brain activity
AAV vector gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811924002751

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http://www.sciencedirect.com/science/article/pii/S1053811924002751

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