Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes
Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obscure. Using mouse models, we show that GTPases of...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2021-01-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/61539 |