Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci

Liver regulatory mechanisms of noncoding variants at lipid and metabolic trait loci

Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for liver disease and lipid-related metabolic traits, although identifying their target genes and molecular mechanisms remains challenging. We predicted target genes at GWAS signals by integrating them with molecu...

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Bibliographic Details
Main Authors: Gautam K. Pandey, Swarooparani Vadlamudi, Kevin W. Currin, Anne H. Moxley, Jayna C. Nicholas, Jessica C. McAfee, K. Alaine Broadaway, Karen L. Mohlke
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:HGG Advances
Subjects:
CRISPR-interference
chromatin accessibility
cholesterol metabolism
genome-wide association studies
liver
hepatocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247724000149

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http://www.sciencedirect.com/science/article/pii/S2666247724000149

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