Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats.

Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats.

BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization. Inhibitors of type 4 phosphodiesterases are potent anti-inflammatory drugs now proposed for lung disorders. The current study was undertaken to determi...

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Main Authors: Céline Méhats, Marie-Laure Franco-Montoya, Olivier Boucherat, Emmanuel Lopez, Thomas Schmitz, Elodie Zana, Danièle Evain-Brion, Jacques Bourbon, Christophe Delacourt, Pierre-Henri Jarreau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2563688?pdf=render

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http://europepmc.org/articles/PMC2563688?pdf=render

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