Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing

Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing

Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro model for disease modelling and regenerative medicine. Here, we e...

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Bibliographic Details
Main Authors: Manon C. Bouwmeester, Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, Luc J. W. van der Laan, Juliette Legler, Kerstin Schneeberger, Nynke I. Kramer, Bart Spee
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
drug-induced liver injury
hepatic in vitro model
hepatotoxicity
intrahepatic cholangiocyte organoids
hepatocyte-like cells
Online Access:https://www.mdpi.com/1420-3049/28/2/621

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https://www.mdpi.com/1420-3049/28/2/621

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