RUNX1 upregulation via disruption of long-range transcriptional control by a novel t(5;21)(q13;q22) translocation in acute myeloid leukemia

RUNX1 upregulation via disruption of long-range transcriptional control by a novel t(5;21)(q13;q22) translocation in acute myeloid leukemia

Abstract RUNX1 encodes a Runt-related transcription factor that is critical for hematopoiesis. In this study, through a combinatorial molecular approach, we characterized a novel t(5;21)(q13;q22) translocation involving RUNX1 that was acquired during the progression of myelodysplastic syndrome to ac...

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Bibliographic Details
Main Authors: Chi-Keung Cheng, Terry H. Y. Wong, Thomas S. K. Wan, Angela Z. Wang, Natalie P. H. Chan, Nelson C. N. Chan, Chi-Kong Li, Margaret H. L. Ng
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Cancer
Subjects:
MDS
AML
RUNX1
Chromosomal translocation
cis-regulatory element
Online Access:http://link.springer.com/article/10.1186/s12943-018-0881-2

Internet

http://link.springer.com/article/10.1186/s12943-018-0881-2

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